Overview

The HOMA project undertakes a series of systematic reviews to evaluate the clinical efficacy, effectiveness, and safety of homeopathic preparations (HPs) in the treatment and prevention of various health conditions.

Aims

  • To address gaps in the existing evidence base by analyzing both randomized and non-randomized studies through a comprehensive and methodologically rigorous approach.
  • Respecting the nature of homeopathy as a whole medical system, by considering not only internal validity and reporting quality, but also model validity, external validity and patient-centered outcomes.
  • To develop living systematic reviews that will regularly incorporate new evidence as it becomes available, using this website as a portal.

Vision

  • To better understand if and under which conditions HPs may offer clinical benefits
  • To inform future research by identifying methodological and evidence-related gaps.
  • To inform the societal discussion on how to integrate the research findings in healthcare systems, based on a systems orientated framing.

Methodological Approach

  • Systematic reviews conducted according to PRISMA-P and Cochrane guidelines
  • Inclusion of both randomized controlled trials (RCTs) and non-randomized studies (NRSIs)
  • Focus on selected health conditions based on expert panel consensus
  • Comprehensive literature search across multiple databases and grey literature
  • Use of homeopathy-specific tools (e.g. CATHIS, iCAT_SR) to assess model validity and complexity
  • Assessing risk of bias with ROB 2 (RCTs) and ROBINS-I (NRSIs)
  • Grading the certainty of evidence using the GRADE framework
  • Meta-analysis when feasible; narrative synthesis (SWiM) otherwise
  • Patient perspectives and real-world complexity considered throughout

The full methodological details are available in the template protocol which has been published on a preprint server.

Ongoing and Planned Subprojects

(Updated regularly based on HOMA project progress)

  • Insomnia
    Evaluation of homeopathic preparations for insomnia.
  • Hypertension
    Systematic review of clinical studies on blood pressure regulation using homeopathy.
  • Female Hormone Regulation
    Focus on menstrual disorders, menopausal symptoms, and hormone-related conditions.
  • Acute Diarrhoea
    Assessment of homeopathy for symptom management in acute diarrhoeal illness.

Further projects will follow in due course based on available evidence and emerging research priorities.

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